3-Hydroxyhippuric acid

• Description:

  3-Hydroxyhippuric acid is an acyl glycine. 3-Hydroxyhippuric acid inhibits kynureninase (Ki = 60 μM) . 3-Hydroxyhippuric acid is found in higher concentrations in autistic group than in the controls. 3-Hydroxyhippuric acid is a marker of Clostridium species, and has a positive correlation with the level of Clostridia. 3-Hydroxyhippuric acid is one of the main metabolites formed from the catechin diet and wine polyphenol diets[1][2][3].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/3-Hydroxyhippuric_acid.html

• Purity:

  99.83

• Solubility:

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles:

  O=C(O)CNC(C1=CC=CC(O)=C1)=O

• Molecular Formula:

  C9H9NO4

• Molecular Weight:

  195.17

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Xiong, X., et al., (2016) . Urinary 3- (3-Hydroxyphenyl) -3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders. BioMed research international, 2016, 9485412.|[2]Gonthier, M. P., et al., (2003) . Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols. The Journal of nutrition, 133 (2), 461–467.|[3]Lima, S., Kumar, S., (2009) . Crystal structure of the Homo sapiens kynureninase-3-hydroxyhippuric acid inhibitor complex: insights into the molecular basis of kynureninase substrate specificity. Journal of medicinal chemistry, 52 (2), 389–396.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite; Microbial Metabolite

• CAS Number:

  [1637-75-8]