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Coclaurine

CAT: 0804-HY-N3610-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N3610-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription[1][2][3][4].
CAS Number
486-39-5
UNSPSC
12352005
Target
NAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/coclaurine.html
Purity
98.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=CC2=C(C=C1OC)CCN[C@H]2CC3=CC=C(O)C=C3
Molecular Formula
C17H19NO3
Molecular Weight
285.34
References & Citations
[1]Sowemimo BO, et al. The isolation of stepharine and coclaurine from Sarcopetalum harveyanum. Lloydia. 1972 Mar;35 (1) :90-1.|[2]Matthew J. Cheesman . Oceania: Antidepressant Medicinal Plants. Herbal Medicine in Depression. 2016, 483-527.|[3]Al-Zahrani, M. H. and Alghamdi, R. A. (2022) “In Silico Molecular Docking Analysis of the Potential role of Reticuline and Coclaurine as Anti-colorectal Cancer Alkaloids”, Journal of Pharmaceutical Research International, 34 (1A), pp. 33–42.|[4]Hu, S. Y., et al., (2024) . Stephania tetrandra and Its Active Compound Coclaurine Sensitize NSCLC Cells to Cisplatin through EFHD2 Inhibition. Pharmaceuticals (Basel, Switzerland), 17 (10), 1356.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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