Cyclizine

• Description :

  Cyclizine, a piperazine-derivative, is a potent and selective histamine H1 receptor antagonist. Cyclizine can be used for the research of nausea, vomiting, and dizziness[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cyclizine.html

• Concentration :

  10mM

• Purity :

  98.64

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1

• Molecular Formula :

  C18H22N2

• Molecular Weight :

  266.38

• Precautions :

  H301

• References & Citations :

  [1]Králová J, et, al. The effects of H1-antihistamines on the nitric oxide production by RAW 264.7 cells with respect to their lipophilicity. Int Immunopharmacol. 2009 Jul;9 (7-8) :990-5.|[2]Church MK, et, al. Inhibition of histamine release from human lung in vitro by antihistamines and related drugs. Br J Pharmacol. 1980 Aug;69 (4) :663-7.|[3]Leza JC, et, al. Effects of antihistaminics on locomotor activity in mice. Comparison with opiate and amphetamine-induced hyperactivity. Gen Pharmacol. 1991;22 (2) :293-6.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  H1 Receptor

• CAS Number :

  [82-92-8]