Genistein

• UNSPSC Description:

  Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis.

• Target Antigen:

  Apoptosis; Autophagy; EGFR; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Autophagy;JAK/STAT Signaling;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Genistein.html

• Solubility:

  DMSO : ≥ 100 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  OC1=C2C(OC=C(C3=CC=C(O)C=C3)C2=O)=CC(O)=C1

• Molecular Weight:

  270.24

• References & Citations:

  [1]Peterson G, et al. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ. 1996 Oct;7(10):1345-51.|[2]Ding S, et al. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein's Beneficial Roles on Lipid Metabolism. PLoS One. 2016 May 12;11(5):e0155352.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Phase 4

• CAS Number:

  446-72-0