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Lappaol F

CAT: 0804-HY-N7223Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N7223Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lappaol F, a lignin, is an anticancer agent. Lappaol F inhibits YAP mRNA and protein level. Lappaol F inhibits tumor cell growth by inducing cell cycle arrest. Lappaol F induces cancer cell apoptosis, and inhibits tumor growth. Lappaol F can be isolated from Arctium lappa Linne (Asteraceae) [1].
CAS Number
69394-17-8
UNSPSC
12352005
Target
Apoptosis; YAP
Type
Natural Products
Related Pathways
Apoptosis; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lappaol-f.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O=C1OC[C@H](CC2=CC(OC)=C(O[C@H](C3=CC=C(O)C(OC)=C3)[C@H]4CO)C4=C2)[C@H]1CC5=CC(OC)=C(O[C@H](C6=CC=C(O)C(OC)=C6)[C@H]7CO)C7=C5
Molecular Formula
C40H42O12
Molecular Weight
714.75
References & Citations
[1]Li X, et al. Lappaol F, an anticancer agent, inhibits YAP via transcriptional and post-translational regulation. Pharm Biol. 2021 Dec;59 (1) :619-628. |[2]Sun Q, et al. Lappaol F, a novel anticancer agent isolated from plant arctium Lappa L. Mol Cancer Ther. 2014 Jan;13 (1) :49-59.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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