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Aplithianines A

CAT: 0804-HY-N12399Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N12399Size:1 Each
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Description
Aplithianines A is a potent inhibitor against J-PKAcα with an IC50 of 1 μM , and inhibits wild-type PKA with an IC50 of 84 nM. Aplithianines A inhibits J-PKAcα catalytic activity by competitively binding to the ATP pocket[1].
CAS Number
3027425-38-0
UNSPSC
12352005
Target
PKA
Type
Natural Products
Related Pathways
Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/aplithianines-a.html
Solubility
10 mM in DMSO
Smiles
CN1C=NC=C1C(SCC2)=CN2C3=NC=NC4=C3N=CN4
Molecular Formula
C13H13N7S
Molecular Weight
299.35
References & Citations
[1]Du L, et al. Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases. J Nat Prod. 2023;86 (10) :2283-2293. IF: 5.1 Q1 B2
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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MBS5824634Aplithianines A

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