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Pseudouridine

CAT: 0804-HY-113061-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113061-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS) -related leukemia.[1][2][3][4][5].
CAS Number
1445-07-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA/RNA Synthesis; Endogenous Metabolite; Nucleoside Antimetabolite/Analog
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pseudouridine.html
Purity
99.94
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CNC2=O)O[C@@H]1CO
Molecular Formula
C9H12N2O6
Molecular Weight
244.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Carlile TM, et al. Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells. Nature. 2014 Nov 6;515 (7525) :143-6.|[2]M Charette, et al. Pseudouridine in RNA: what, where, how, and why. IUBMB Life. 2000 May;49 (5) :341-51.|[3]Junhui Ge, et al. RNA pseudouridylation: new insights into an old modification. Trends Biochem Sci. 2013 Apr;38 (4) :210-8.|[4]Anne C Rintala-Dempsey, et al. Eukaryotic stand-alone pseudouridine synthases - RNA modifying enzymes and emerging regulators of gene expression? RNA Biol. 2017 Sep 2;14 (9) :1185-1196.|[5]Malcovati L, et al. Pseudouridine-modified tRNA fragments repress aberrant protein synthesis and predict leukaemic progression in myelodysplastic syndrome. Nat Cell Biol. 2022 Mar;24 (3) :299-306.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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