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Thymoquinone

CAT: 0804-HY-D0803-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-D0803-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation [1][2][3][4][5].
CAS Number
490-91-5
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Akt; Apoptosis; PI3K; VEGFR
Type
Natural Products
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/thymoquinone.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(C)=CC(C(C(C)C)=C1)=O
Molecular Formula
C10H12O2
Molecular Weight
164.20
Precautions
H302, H315, H319, H335
References & Citations
[1]Zeinvand-Lorestani H, et al. Protective role of thymoquinone against paraquat-induced hepatotoxicity in mice. Pestic Biochem Physiol. 2018 Jun;148:16-21. |[2]Nagi MN, et al. Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacol Res. 2000 Mar;41 (3) :283-9. |[3]Jafri SH, et al. Thymoquinone and cisplatin as a therapeutic combination in lung cancer: In vitro and in vivo. J Exp Clin Cancer Res. 2010 Jul 1;29 (1) :87.|[4]Elibol B, et al. Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model. Phytomedicine. 2020 Dec;79:153324. |[5]Su X, et al. Thymoquinone inhibits inflammation, neoangiogenesis and vascular remodeling in asthma mice. Int Immunopharmacol. 2016 Sep;38:70-80.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Phase 3
Isoform
Akt; PI3K; VEGFR2/KDR/Flk-1

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CatalogName
FT09858-01Thymoquinone

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