Gepirone

• Description:

  Gepirone is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/gepirone.html

• Purity:

  99.88

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 33.33 mg/mL (ultrasonic)

• Smiles:

  O=C(CC(C)(C)C1)N(CCCCN2CCN(C3=NC=CC=N3)CC2)C1=O

• Molecular Formula:

  C19H29N5O2

• Molecular Weight:

  359.47

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1] Mendelson SD, et al. Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone. Eur J Pharmacol. 1986 Dec 16;132 (2-3) :323-6.|[2]Blier P, et al. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse. 1987;1 (5) :470-80.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  5-HT1 Receptor; mLAG-3

• CAS Number:

  [83928-76-1]