CARM1-IN-3 (dihydrochloride)

CARM1-IN-3 (dihydrochloride)

• UNSPSC Description: CARM1-IN-3 dihydrochloride (compound 17b) is a potent and selective co-activator associated arginine methyltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively[1].
• Target Antigen: Histone Methyltransferase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/carm1-in-3-dihydrochloride.html
• Solubility: DMSO : 50 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: CNCCN1CCC(C2=CC3=C(N=C(C4=C(OC)C=CC=C4OC)N3)C(C)=C2)CC1.Cl.Cl
• Molecular Weight: 481.46
• References & Citations: [1]Wan H, et al. Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)--Hit to Lead studies. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5063-6.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported