TCO-PEG-TCO (MW 5000)

TCO-PEG-TCO (MW 5000)

• UNSPSC Description: TCO-PEG-TCO (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. TCO-PEG-TCO (MW 5000) is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
• Target Antigen: PROTAC Linkers
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tco-peg-tco-mw-5000.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NCCOCCNC(OC1CC/C=C\CCC1)=O)OC2CC/C=C\CCC2.[MW 5000].[n]
• Molecular Weight: 5000(Average)
• References & Citations: [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported