3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid

3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid

• CAS Number: 153666-19-4
• UNSPSC Description: 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) is a sialic acid. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid protects the oligo/(poly)sialyl chains from exosialidases at nonreducing terminal, and plays a role in egg activation of salmonid fish[1]. 3-Deoxy-D-glycero-D-galacto-2-nonulosonic acid is abundant in fetal cord red blood cells and malignant human ovarian cancer cells[2].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/3-deoxy-d-glycero-d-galacto-2-nonulosonic-acid.html
• Solubility: 10 mM in DMSO
• Smiles: OC[C@@H](O)[C@H]([C@]1([H])OC(O)(C[C@@H]([C@H]1O)O)C(O)=O)O
• Molecular Weight: 268.22
• References & Citations: [1]Nadano D, et al., A naturally occurring deaminated neuraminic acid, 3-deoxy-D-glycero-D-galacto-nonulosonic acid (KDN). Its unique occurrence at the nonreducing ends of oligosialyl chains in polysialoglycoprotein of rainbow trout eggs. J Biol Chem. 1986 Sep 5;261(25):11550-7.|[2]Inoue S, et al., Identification of free deaminated sialic acid (2-keto-3-deoxy-D-glycero-D-galacto-nononic acid) in human red blood cells and its elevated expression in fetal cord red blood cells and ovarian cancer cells. J Biol Chem. 1998 Oct 16;273(42):27199-204.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported