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RIPGBM

CAT: 0804-HY-122910-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-122910-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPGBM is a selective inducer of apoptosis in glioblastoma multiforme (GBM) cancer stem cells (CSCs) with an EC50 of ≤500 nM[1].
CAS Number
355406-76-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/RIPGBM.html
Purity
99.95
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
CC(N(C(C1=O)=C(NCC2=CC=CC=C2)C(C3=C1C=CC=C3)=O)CC4=CC=C(F)C=C4)=O
Molecular Formula
C26H21FN2O3
Molecular Weight
428.45
Precautions
H302, H315, H319
References & Citations
[1]Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116 (13) :6435-6440.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Ripgbm
CAS Number355406-76-7
PubChem CID3793001
IUPAC NameN-[3-(benzylamino)-1,4-dioxonaphthalen-2-yl]-N-[(4-fluorophenyl)methyl]acetamide
Molecular FormulaC26H21FN2O3
Molecular Weight428.5
XLogP4.3
Topological Polar Surface Area66.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count32
Formal Charge0
Complexity750
SMILES
CC(=O)N(CC1=CC=C(C=C1)F)C2=C(C(=O)C3=CC=CC=C3C2=O)NCC4=CC=CC=C4
InChI
InChI=1S/C26H21FN2O3/c1-17(30)29(16-19-11-13-20(27)14-12-19)24-23(28-15-18-7-3-2-4-8-18)25(31)21-9-5-6-10-22(21)26(24)32/h2-14,28H,15-16H2,1H3
InChIKey
COATXBHZYVUJQP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ripgbm
CAS: 355406-76-7
CID: 3793001
Formula: C26H21FN2O3
MW: 428.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight428.5
XLogP34.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass428.15362070
Monoisotopic Mass428.15362070
Topological Polar Surface Area66.5 Ų
Heavy Atom Count32
Formal Charge0
Complexity750
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA3174-10RIPGBM
A13441-25RIPGBM 25mg
A13441-100RIPGBM 100mg
A13441-5RIPGBM 5mg
A13441-50RIPGBM 50mg
A13441-2RIPGBM 2mg
A13441-200RIPGBM 200mg
A13441-10RIPGBM 10mg
A13441-10mM-DRIPGBM 10mM * 1mL in DMSO

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