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Asenapine

CAT: 0804-HY-10121-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10121-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0) . Asenapine can be used in the research of schizophrenia and bipolar disorder[1][2].
CAS Number
65576-45-6
Product Name Alternative
Org 5222
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
5-HT Receptor; Adrenergic Receptor; Dopamine Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Asenapine.html
Purity
99.62
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
ClC1=CC=C2OC3=CC=CC=C3[C@@](C4)([H])[C@](CN4C)([H])C2=C1
Molecular Formula
C17H16ClNO
Molecular Weight
285.77
Precautions
H315, H319, H335
References & Citations
[1]M Shahid, et al. Asenapine: a novel psychopharmacologic agent with a unique human receptor signature. J Psychopharmacol. 2009 Jan;23 (1) :65-73.|[2]Olivia Frånberg, et al. Asenapine, a novel psychopharmacologic agent: preclinical evidence for clinical effects in schizophrenia. Psychopharmacology (Berl) . 2008 Feb;196 (3) :417-29.|[3]Ohyama M, et al. Asenapine reduces anxiety-related behaviours in rat conditioned fear stress model. Acta Neuropsychiatr. 2016 Dec;28 (6) :327-336.|[4]Ene HM, et al. Effects of repeated asenapine in a battery of tests for anxiety-like behaviours in mice. Acta Neuropsychiatr. 2016 Apr;28 (2) :85-91. |[5]Stoner SC, Pace HA. Asenapine: a clinical review of a second-generation antipsychotic. Clin Ther. 2012 May;34 (5) :1023-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
D1 Receptor; D2 Receptor; D3 Receptor; D4 Receptor; H1 Receptor; H2 Receptor; mLAG-3; MUC2; MUC3; Prostaglandin D Synthase; α adrenergic receptor; α-1 microglobulin
Citation 01
Biomed Pharmacother. 2025 Jan:182:117756.|Biomed Pharmacother. 2025 Jan:182:117756.|Insect Biochem Mol Biol. 2025 May:180:104312.|Int J Biol Macromol. 2023 Aug 30:247:125703.

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