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Col003

CAT: 0804-HY-124817-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-124817-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen binding site on Hsp47 (IC50=1.8 μM) . Col003 discourages the interaction of Hsp47 with collagen and inhibits collagen secretion by destabilizing the collagen triple helix. Col003 can be used for the investigation of fibrosis[1]
CAS Number
328565-16-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/col003.html
Purity
99.87
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=CC1=CC(CC2=CC=CC=C2)=CC([N+]([O-])=O)=C1O
Molecular Formula
C14H11NO4
Molecular Weight
257.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Ito S, et al. A small-molecule compound inhibits a collagen-specific molecular chaperone and could represent a potential remedy for fibrosis. J Biol Chem. 2017 Dec 8;292 (49) :20076-20085.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP40

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BA4175-100Col003
A18573-500Col003 500mg
A18573-200Col003 200mg
A18573-50Col003 50mg
A18573-25Col003 25mg
A18573-5Col003 5mg
A18573-2Col003 2mg
A18573-100Col003 100mg
A18573-10Col003 10mg

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