NCATS-SM4487

CAT: 0804-HY-132888Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-132888Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NCATS-SM4487 is a highly selective unique dihydropyrimidine inhibitor against GALK1, with an IC50 value of 0.05 μM.

CAS Number

2733617-81-5

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ncats-sm4487.html

Solubility

10 mM in DMSO

Smiles

CN1C=C(C=N1)CNC(C2=C(NC(NC3=NC4=C(C(N)=C(C=C4)F)O3)=NC2C5=C(C=C(C=C5)C)Cl)C)=O

Molecular Formula

C25H24ClFN8O2

Molecular Weight

522.96

References & Citations

[1]Liu L, et al. Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J Med Chem. 2021 Sep 23;64 (18) :13551-13571.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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