Desmorpholinyl Navitoclax-NH-Me

Desmorpholinyl Navitoclax-NH-Me

• Product Name Alternative: Desmorpholinyl ABT-263-NH-Me
• CAS Number: 2365172-82-1
• UNSPSC Description: Desmorpholinyl Navitoclax-NH-Me is a Bcl-xL inhibitor. Desmorpholinyl Navitoclax-NH-Me and a CRBN ligand for the E3 ubiquitin ligase can be used in the synthesis of PROTAC BCL-XL degrader XZ739 (HY-133557)[1][2].
• Target Antigen: Bcl-2 Family; Ligands for Target Protein for PROTAC
• Type: Reference compound
• Related Pathways: Apoptosis;PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/desmorpholinyl-navitoclax-nh-me.html
• Purity: 98.64
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(C1=CC=C(N2CCN(CC3=C(C4=CC=C(Cl)C=C4)CCC(C)(C)C3)CC2)C=C1)NS(C5=CC(S(=O)(C(F)(F)F)=O)=C(N[C@@H](CSC6=CC=CC=C6)CCNC)C=C5)(=O)=O
• Molecular Weight: 918.55
• References & Citations: [1]Guangrong Zheng, et al. Agents de dégradation de protéines bcl-2 pour le traitement du cancer. WO2019144117A1.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported