LY379268

CAT: 0804-HY-103558-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103558-01Size:5 mg
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Description
LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3) . LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects[1][2].
CAS Number
[191471-52-0]
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly379268.html
Purity
99.84
Solubility
0.1 M NaOH : 200 mg/mL (ultrasonic; adjust pH to 8 with NaOH) |H2O : 2 mg/mL (ultrasonic; adjust pH to 10 with NaOH)
Smiles
O=C([C@]1(N)CO[C@@]2([H])[C@H](C(O)=O)[C@@]12[H])O
Molecular Formula
C7H9NO5
Molecular Weight
187.15
References & Citations
[1]J A Monn, et al. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+) -2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740) : identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42 (6) :1027-40.|[2]E F Sharpe, et al. Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo. Br J Pharmacol. 2002 Mar;135 (5) :1255-62.|[3]Juan Turati, et al. Antioxidant and neuroprotective effects of mGlu3 receptor activation on astrocytes aged in vitro. Neurochem Int. 2020 Nov;140:104837.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR2; mGluR3

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532164LY379268
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