LY379268

• Description :

  LY379268 is a potent, selective and brain-penetrant mGlu2/3R agonist with EC50 values of 2.69 nM (mGlu2) and 4.48 nM (mGlu3) . LY379268 has no activity on human mGlu 1a, 4a, 5a or 7a receptors. LY379268 has antioxidant and neuroprotective effects[1][2].

• UNSPSC :

  12352005

• Target :

  MGluR

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ly379268.html

• Purity :

  99.84

• Solubility :

  0.1 M NaOH : 200 mg/mL (ultrasonic; adjust pH to 8 with NaOH) |H2O : 2 mg/mL (ultrasonic; adjust pH to 10 with NaOH)

• Smiles :

  O=C([C@]1(N)CO[C@@]2([H])[C@H](C(O)=O)[C@@]12[H])O

• Molecular Formula :

  C7H9NO5

• Molecular Weight :

  187.15

• References & Citations :

  [1]J A Monn, et al. Synthesis, pharmacological characterization, and molecular modeling of heterobicyclic amino acids related to (+) -2-aminobicyclo[3.1.0] hexane-2,6-dicarboxylic acid (LY354740) : identification of two new potent, selective, and systemically active agonists for group II metabotropic glutamate receptors. J Med Chem. 1999 Mar 25;42 (6) :1027-40.|[2]E F Sharpe, et al. Systemic pre-treatment with a group II mGlu agonist, LY379268, reduces hyperalgesia in vivo. Br J Pharmacol. 2002 Mar;135 (5) :1255-62.|[3]Juan Turati, et al. Antioxidant and neuroprotective effects of mGlu3 receptor activation on astrocytes aged in vitro. Neurochem Int. 2020 Nov;140:104837.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  MGluR2; mGluR3

• CAS Number :

  [191471-52-0]