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NIBR0213

CAT: 0804-HY-18166-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18166-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NIBR-0213 is a potent, orally active and selective S1P1 antagonist with efficacy in experimental autoimmune encephalomyelitis. NIBR-0213 displays potent and comparable potency on human and rat S1P1 (IC50 of 2.0 nM and 2.3 nM, respectively) in GTPγ35S assays[1].
CAS Number
1233332-14-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nibr0213.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 25mg/mL
Smiles
ClC1=CC=C([C@@H](C)NC2=CC=CC(C3=CC(C)=C(C(N[C@@H](C)C(O)=O)=O)C(C)=C3)=C2)C=C1C
Molecular Formula
C27H29ClN2O3
Molecular Weight
464.98
Precautions
H302, H315, H319
References & Citations
[1]Jean Quancard, et al. A potent and selective S1P (1) antagonist with efficacy in experimental autoimmune encephalomyelitis. Chem Biol. 2012 Sep 21;19 (9) :1142-51.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA5477-5NIBR0213

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