2-HBA

• Description:

  2-HBA is a potent inducer of NAD (P) H:quinone acceptor oxidoreductase 1 (NQO1) which can also activate caspase-3 and caspase-10.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Caspase; Quinone Reductase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/2-HBA.html

• Purity:

  99.46

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(/C=C/C1=CC=CC=C1O)/C=C/C2=CC=CC=C2O

• Molecular Formula:

  C17H14O3

• Molecular Weight:

  266.29

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Dinkova-Kostova AT, et al. Bis (2-hydroxybenzylidene) acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway. Cancer Lett. 2007 Jan 8;245 (1-2) :341-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Caspase 10; Caspase 3

• CAS Number:

  [131359-24-5]