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Nilutamide

CAT: 0804-HY-13702-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-13702-01Size:100 mg
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Description
Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties[1][4].
CAS Number
63612-50-0
Product Name Alternative
Nilandron; RU 23908
UNSPSC
12352005
Hazard Statement
H301, H360
Target
Androgen Receptor; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Endocrinology
Assay Protocol
https://www.medchemexpress.com/nilutamide.html
Concentration
10mM
Purity
99.66
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC=C([N+]([O-])=O)C(C(F)(F)F)=C2)C(C(C)(C)N1)=O
Molecular Formula
C12H10F3N3O4
Molecular Weight
317.22
Precautions
H301, H360
References & Citations
[1]Harris MG, et al. Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1993 Jan-Feb;3 (1) :9-25.|[2]Babany G, et al. Inhibitory effects of nilutamide, a new androgen receptor antagonist, on mouse and human liver cytochrome P-450. Biochem Pharmacol. 1989 Mar 15;38 (6) :941-7.|[3]Simard J, et al. Comparison of in vitro effects of the pure antiandrogens OH-flutamide, Casodex, and nilutamide on androgen-sensitive parameters. Urology. 1997 Apr;49 (4) :580-6; discussion 586-9.|[4]Keiser J, Vargas M, Vennerstrom JL. Activity of antiandrogens against juvenile and adult Schistosoma mansoni in mice. J Antimicrob Chemother. 2010 Sep;65 (9) :1991-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Schistosome

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