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L6H21

CAT: 0804-HY-W082785A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W082785A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L6H21, a Chalcone derivative, is an orally active, potent and specific myeloid differentiation 2 (MD-2) inhibitor. L6H21 directly binds to MD-2 protein with a high affinity and low KD value of 33.3 μM, blocking the formation of the LPS-TLR4/MD-2 complex. L6H21 inhibits LPS-induced expression of TNF-α and IL-6 in RAW264.7 macrophages, with IC50 values of 6.58 and 8.59 μM, respectively. L6H21 can be used for alcoholic liver disease, metabolic disturbance and neuroinflammation research[1][2][3].
CAS Number
24533-47-9
UNSPSC
12352005
Hazard Statement
H400
Target
Apoptosis; Bcl-2 Family; Caspase; Interleukin Related; NF-κB; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l6h21.html
Concentration
10mM
Purity
99.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(OC)C=C1)/C=C/C2=CC=CC(OC)=C2OC
Molecular Formula
C18H18O4
Molecular Weight
298.34
Precautions
H400
References & Citations
[1]Kong X, et al. Chalcone Derivative L6H21 Reduces EtOH + LPS-Induced Liver Injury Through Inhibition of NLRP3 Inflammasome Activation. Alcohol Clin Exp Res. 2019 Aug;43 (8) :1662-1671.|[2]Oo TT, et al. L6H21 protects against cognitive impairment and brain pathologies via toll-like receptor 4-myeloid differentiation factor 2 signalling in prediabetic rats. Br J Pharmacol. 2022 Mar;179 (6) :1220-1236.|[3]Yi Wang, et al. MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br J Pharmacol. 2015 Sep;172 (17) :4391-405.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; IL-1; IL-6; NF-κB; NLRP3; TLR4; TNFRSF5/CD40

Alternative Products

CatalogName
BA3033-5L6H21

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