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A-57696

CAT: 0804-HY-P2055Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P2055Size:1 Each
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Description
A-57696 is a cholecystokinin antagonist with selective activity at cortical CCK-B receptors (IC50 = 25 nM) . A-57696 behaves as a competitive antagonist in reversing CCK8-stimulated pancreatic alpha-amylase secretion and phosphatidylinositol degradation. A-57696 fails to induce gallbladder contraction and inhibits CCK8-induced contraction. A-57696 behaves as a partial agonist at CCK-B/gastrin receptors on NCI-H345 cells, achieving 80% of the maximal CCK8 response. A-57696 and CCK8 inhibit each other in a calcium mobilization assay[1].
CAS Number
125598-87-0
UNSPSC
12352209
Target
Endogenous Metabolite
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/a-57696.html
Smiles
O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=CC=C1)C(NN)=O)=O)=O)[C@H](CC2=CNC3=CC=CC=C23)NC(OC(C)(C)C)=O
Molecular Formula
C35H47N7O8
Molecular Weight
693.79
References & Citations
[1]Distinct requirements for activation at CCK-A and CCK-B/gastrin receptors: studies with a C-terminal hydrazide analogue of cholecystokinin tetrapeptide (30-33)
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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