α-Ionone

• Description :

  α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro[1].

• Product Name Alternative :

  Alpha-Ionone

• UNSPSC :

  12352211

• Hazard Statement :

  H334

• Target :

  Apoptosis; Hippo (MST) ; Olfactory Receptor; YAP

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; GPCR/G Protein; Neuronal Signaling; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/α-ionone.html

• Purity :

  94.30

• Solubility :

  DMSO : 200 mg/mL (ultrasonic)

• Smiles :

  CC1=CCCC(C)(C)C1/C=C/C(C)=O

• Molecular Formula :

  C13H20O

• Molecular Weight :

  192.30

• Precautions :

  H334

• References & Citations :

  [1]Yoon YE, et al. A Food Odorant, α-Ionone, Inhibits Skin Cancer Tumorigenesis by Activation of OR10A6. Mol Nutr Food Res. 2024 Aug;68 (15) :e2400085.|[2]Ozgen U, et al. A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews. Molecules. 2010 Apr 12;15 (4) :2593-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [127-41-3]