α-Ionone

• UNSPSC Description:

  α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro[1].

• Target Antigen:

  Hippo (MST); YAP

• Type:

  Natural Products

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/α-ionone.html

• Purity:

  94.30

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  CC1=CCCC(C)(C)C1/C=C/C(C)=O

• Molecular Weight:

  192.30

• References & Citations:

  [1]Yoon YE, et al. A Food Odorant, α-Ionone, Inhibits Skin Cancer Tumorigenesis by Activation of OR10A6. Mol Nutr Food Res. 2024 Aug;68(15):e2400085.|[2]Ozgen U, et al. A new sulfated alpha-ionone glycoside from Sonchus erzincanicus Matthews. Molecules. 2010 Apr 12;15(4):2593-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  127-41-3