Carbaryl

• Description :

  Carbaryl is the inhibitor for acetylcholinesterase that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide[1][2].

• CAS Number :

  [63-25-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335, H350, H360

• Target :

  Apoptosis; Cholinesterase (ChE) ; Insecticide; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Others

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/carbaryl.html

• Concentration :

  10mM

• Purity :

  99.95

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(OC1=C2C=CC=CC2=CC=C1)NC

• Molecular Formula :

  C12H11NO2

• Molecular Weight :

  201.22

• Precautions :

  H302, H315, H319, H335, H350, H360

• References & Citations :

  [1]Nancy E Todd, et al. Effects of Sevin (Carbaryl Insecticide) on Early Life Stages of Zebrafish (Danio Rerio) . Ecotoxicol Environ Saf. 2002 Oct;53 (2) :267-72.|[2]Blevins RD, et al., Effects of carbaryl and dieldrin on the growth, protein content, and phospholipid content of HeLa cells. J Agric Food Chem. 1975 May-Jun;23 (3) :377-82.|[3]Schock EN, et al., The effects of carbaryl on the development of zebrafish (Danio rerio) embryos. Zebrafish. 2012 Dec;9 (4) :169-78.|[4]Muthaiah VP, et al., Neuroprotective role of naringenin on carbaryl induced neurotoxicity in mouse neuroblastoma cells. J Pharmacol Pharmacother. 2013 Jul;4 (3) :192-7.|[5]Jorsaraei SG, et al., Immunotoxicity effects of carbaryl in vivo and in vitro. Environ Toxicol Pharmacol. 2014 Nov;38 (3) :838-44.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported