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Enterobactin

CAT: 0804-HY-128525-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128525-01Size:1 mg
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Description
Enterobactin is a siderophore produced by Gram-negative bacteria and has an extremely high affinity for iron. During the process of Salmonella typhimurium infecting macrophages, Enterobactin can not only help bacteria uptake iron but also reduce the antibacterial activity of macrophages. In addition, Enterobactin is also involved in the oxidative stress response of Escherichia coli. Enterobactin can be hydrolyzed by Fes in the cell and exert antioxidant effects by scavenging free radicals[1][2].
CAS Number
28384-96-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Bacterial; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/enterobactin.html
Concentration
10mM
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1OC[C@H](NC(C2=CC=CC(O)=C2O)=O)C(OC[C@H](NC(C3=CC=CC(O)=C3O)=O)C(OC[C@@H]1NC(C4=CC=CC(O)=C4O)=O)=O)=O
Molecular Formula
C30H27N3O15
Molecular Weight
669.55
Precautions
H315, H319
References & Citations
[1]Saha P, et al. The bacterial siderophore enterobactin confers survival advantage to Salmonella in macrophages. Gut Microbes. 2019;10 (3) :412-423.|[2]Peralta DR, et al. Enterobactin as Part of the Oxidative Stress Response Repertoire. PLoS One. 2016 Jun 16;11 (6) :e0157799.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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