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WRR139

CAT: 0804-HY-129225-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129225-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WRR139 is a peptide vinyl sulfone involving in disease processes such as inflammation and cancer. WRR139 is also a cytosolic enzyme N-glycanase 1 (NGLY1) and Nrf1 inhibitor. WRR139 enhances Carfilzomib cytotoxicity against cancer cells[1].
CAS Number
2138924-36-2
UNSPSC
12352005
Target
Keap1-Nrf2; Transglutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/wrr139.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCC(C)C)[C@@H](NC(/C=C/S(C1=CC=C(C)C=C1)(=O)=O)=O)CCC2=CC=CC=C2
Molecular Formula
C25H32N2O4S
Molecular Weight
456.60
References & Citations
[1]Tomlin FM, et al. Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity. ACS Cent Sci. 2017 Nov 22;3 (11) :1143-1155.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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