BCI

• Description :

  BCI ((E) -BCI) is a DUSP6 (dual specificity phosphatase 6) inhibitor. BCI shows anti-inflammatory activity and decreases reactive oxygen species (ROS) production. BCI can be used in inflammatory disease research[1][2].

• Product Name Alternative :

  (E) -BCI

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Phosphatase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/bci.html

• Concentration :

  10mM

• Purity :

  99.73

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C1/C(C(NC2CCCCC2)C3=C1C=CC=C3)=C/C4=CC=CC=C4

• Molecular Formula :

  C22H23NO

• Molecular Weight :

  317.43

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Korotchenko VN, et al. In vivo structure-activity relationship studies support allosteric targeting of a dual specificity phosphatase. Chembiochem. 2014 Jul 7;15 (10) :1436-45.|[2]Zhang F, et al. DUSP6 Inhibitor (E/Z) -BCI Hydrochloride Attenuates Lipopolysaccharide-Induced Inflammatory Responses in Murine Macrophage Cells via Activating the Nrf2 Signaling Axis and Inhibiting the NF-κB Pathway. Inflammation. 2019 Apr;42 (2) :672-681.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  BioRxiv. 2024 Feb 5.|Cells. 2022 Feb 19;11 (4) :732.|Dis Model Mech. 2023 May 1;16 (5) :dmm049662.|FASEB J. 2025 Jul 15;39 (13) :e70780.|Int Immunopharmacol. 2024 Sep 30;143 (Pt 1) :113280.|J Nanobiotechnology. 2025 Jun 6;23 (1) :422.|Kaohsiung J Med Sci. 2023 Mar;39 (3) :254-265.|Neural Regen Res. 2023 Aug;18 (8) :1743-1749.|Sci Rep. 2025 May 24;15 (1) :18115.|Cancer Med. 2024 Oct;13 (19) :e70276.|Cancers (Basel) . 2023 Sep 6;15 (18) :4442.|Cell Rep. 2025 Feb 20;44 (3) :115340.|Development. 2023 Mar 1;150 (5) :dev201090.|Phytother Res. 2023 Jul;37 (7) :2979-2994.|Transplant Proc. 2025 Aug 11:S0041-1345 (25) 00350-1.|University of Washington. 2025.

• CAS Number :

  [1245792-51-1]