B I09

• Description :

  B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

• UNSPSC :

  12352005

• Target :

  IRE1

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/B_I09.html

• Purity :

  99.35

• Solubility :

  DMSO : 11.11 mg/mL (ultrasonic)

• Smiles :

  OC1=CC=C(C2=C(CNCC2)C3=O)C(O3)=C1C4OCCCO4

• Molecular Formula :

  C16H17NO5

• Molecular Weight :

  303.31

• References & Citations :

  [1]Ranatunga S, et al. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57 (10) :4289-301.|[2]Tang CH, et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014 Jun;124 (6) :2585-98.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1607803-67-7]