B I09

• UNSPSC Description:

  B I09 is an IRE-1 RNase inhibitor, with an IC50 of 1230 nM.

• Target Antigen:

  IRE1

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/B_I09.html

• Purity:

  98.82

• Solubility:

  DMSO : 11.11 mg/mL (ultrasonic)

• Smiles:

  OC1=CC=C(C2=C(CNCC2)C3=O)C(O3)=C1C4OCCCO4

• Molecular Weight:

  303.31

• References & Citations:

  [1]Ranatunga S, et al. Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity. J Med Chem. 2014 May 22;57(10):4289-301.|[2]Tang CH, et al. Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014 Jun;124(6):2585-98.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  1607803-67-7