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YUM70

CAT: 0804-HY-138364-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138364-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YUM70 is a potent and selective inhibitor of glucose-regulated protein 78 (GRP78), with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer. YUM70 also has in vivo efficacy in a pancreatic cancer xenograft model[1].
CAS Number
423145-35-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/yum70.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCC(NC(C1=CC=C(OCO2)C2=C1)C3=CC(Cl)=C4C=CC=NC4=C3O)=O
Molecular Formula
C21H19ClN2O4
Molecular Weight
398.84
Precautions
H302, H315, H319, H335
References & Citations
[1]Samanta S, et, al. The hydroxyquinoline analog YUM70 inhibits GRP78 to induce ER stress-mediated apoptosis in pancreatic cancer. Cancer Res. 2021 Feb 2; canres.1540.2020.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70

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