KV1.3-IN-1

• UNSPSC Description:

  KV1.3-IN-1 (Compound trans-18) is a KV1.3 channel inhibitor (IC50: 230 nM and 26.12 nM in Ltk cells and PHA-activated T-lymphocytes respectively). KV1.3-IN-1 impairs intracellular Ca2+ signaling. KV1.3-IN-1 inhibits T-cell activation, proliferation, and colony formation[1].

• Target Antigen:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/kv1-3-in-1.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic;heat to 60°C)

• Smiles:

  O=C(O[C@H]1CC[C@](C2=CSC=C2)(CNC(C3=CC=CC=C3OC)=O)CC1)NCCC

• Molecular Weight:

  430.56

• References & Citations:

  [1]Gubič Š, et al. Immunosuppressive effects of new thiophene-based KV1.3 inhibitors. Eur J Med Chem. 2023 Jun 25;259:115561.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported