Denosumab

• Description:

  Denosumab is a human monoclonal antibody that targets the protein RANKL. Denosumab binds to the receptor activator of nuclear factor kappa-B ligand (RANKL) and prevents its binding to the RANK receptor (KD of 0.003 nM for human RANKL) . Denosumab promotes proliferation and spermatogenesis. Denosumab prevents bone resorption through inhibition of the NF-κB pathway. Denosumab can be used in bone-related studies[1][2][3][4][5][6][7].

• Product Name Alternative:

  AMG-162

• UNSPSC:

  12352203

• Target:

  Apoptosis; Caspase; NF-κB; RANKL/RANK

• Type:

  Inhibitory Antibodies

• Related Pathways:

  Apoptosis; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/denosumab.html

• Purity:

  99.10

• Solubility:

  H2O

• Smiles:

  [Denosumab]

• Molecular Formula:

  C6404H9908N1724O2004S50

• Molecular Weight:

  (145.16 kDa)

• References & Citations:

  [1]1. Moen MD, et al. Denosumab: a review of its use in the treatment of postmenopausal osteoporosis. Drugs Aging. 2011;28 (1) :63-82. |[2]2. Kendler DL, et al. Denosumab in the Treatment of Osteoporosis: 10 Years Later: A Narrative Review. Adv Ther. 2022 Jan;39 (1) :58-74. |[3]3. Dell'Aquila E, et al. Denosumab for cancer-related bone loss. Expert Opin Biol Ther. 2020 Nov;20 (11) :1261-1274. |[4]4. Mosch A, et al. Physiological concentrations of denosumab enhance osteogenic differentiation in human mesenchymal stem cells of the jaw bone. Arch Oral Biol. 2019 May;101:23-29.|[5]5. Shangguan L, et al. Denosumab ameliorates osteoarthritis by protecting cartilage against degradation and modulating subchondral bone remodeling. Regen Ther. 2024 Mar 26;27:181-190. |[6]6. Kondegowda NG, et al. Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway. Cell Metab. 2015 Jul 7;22 (1) :77-85. |[7]7. Andreassen CH, et al. Denosumab stimulates spermatogenesis in infertile men with preserved Sertoli cell capacity. Cell Rep Med. 2024 Oct 15;5 (10) :101783.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4°C for 2 years, do not freeze

• Scientific Category:

  Inhibitory Antibodies

• Clinical Information:

  Launched

• Isoform:

  Caspase 3

• CAS Number:

  615258-40-7