Amyloid Beta 1-42 Oligomer Antibody: PerCP
CAT:
400-SMC-619D-PCP
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Amyloid Beta 1-42 Oligomer Antibody: PerCP
- Background: Our amyloid beta oligomer antibody (clone 1C1) has been tested for specificity against synthetic AB 1-42 aggregates, with higher specificity to oligomers demonstrated. In the brain, amyloid beta peptide (Aβ) is generated by protease cleavage of amyloid precursor protein (APP), which aggregates into oligomers, protofibrils, fibrils and ultimately plaques in neurodegenerative diseases. The accumulation of Aβ plaques in the brain is considered a hallmark of Alzheimer’s disease (AD), and most of the drugs tested for AD in the past 20 years have targeted amyloid beta accumulation (1). The immunogen used was our Amyloid Beta 1-42 (Aβ42) Oligomers are generated from Amyloid Beta Peptide 1-42 pre-treated with 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as previously published (2,3).
- Description: Rabbit Anti-Human Amyloid Beta 1-42 Oligomer Recombinant Monoclonal IgG
- Specifications: Amyloid Beta 1-42 oligomers
- Product Name Alternative: Abeta Oligomers Antibody, APP Antibody
- Synonyms: Amyloid Beta 1-42 Oligomer Antibody, Clone 1C1: PerCP
- CAS Number: 9007-83-4
- UNSPSC: 12352203
- Gene ID: 351 (APP)
- Swiss Prot: P05067
- Cellular Locus: Membrane (Secreted)
- Host: Rabbit
- Species Reactivity: Human
- Immunogen: Amyloid beta 1-42 oligomers (StressMarq Catalog# SPR-488)
- Target: Amyloid Beta 1-42 Oligomer
- Clonality: Recombinant
- Isotype: IgG
- Clone: 1C1
- Conjugation: PerCP
- Tissue Specificity: CNS, Blood
- Validated Applications: WB, IHC, ICC/IF, ELISA
- Purification: Protein A Purified
- Limit Of Detection: A 1:10,000 dilution of SMC-619 was sufficient for detection of 1ug of AB 1-42 oligomers by western blot analysis with goat-anti-rabbit:HRP as the secondary and by self-sandwich ELISA analysis (capture at 1 ug/mL, detection at 0.2 ug/mL).
- Concentration: 0.5 mg/ml
- Dilution: WB, ELISA (1:1000 - 1:10,000); optimal dilutions for assays should be determined by the user.
- Weight: 0.1
- Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- References & Citations: 1. Panza et al. 2019. Nat Rev Neurol. 15:73-88 https://doi.org/10.1038/s41582-018-0116-6 2. Stine et al. 2003. JBC. 278(13):11612-22. doi: 10.1074/jbc.M210207200 3. Ahmed et al. 2010. Nature Structural & Molecular Biology. 17(5):561 doi: 10.1038/nsmb.1799