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Cleistanthin B

CAT: 0804-HY-N9351Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N9351Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].
CAS Number
30021-77-3
Product Name Alternative
Diphyllin O-glucoside
UNSPSC
12352005
Target
SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Infection; Metabolic Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cleistanthin-b.html
Purity
98.19
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)=C2CO1
Molecular Formula
C27H26O12
Molecular Weight
542.49
References & Citations
[1]Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9 (3) :471.|[2]Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6 (4) :383-388.|[3]Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4 (2) :73-7.|[4]Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5 (4) :109-14.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
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