Cleistanthin B

• Description:

  Cleistanthin B (Diphyllin O-glucoside) is an orally active arylnaphthalene lignan lactone glycoside. Cleistanthin B exhibits anti-SARS-CoV-2 effects in Vero cells, with EC50 of 6.51 μM. Cleistanthin B also exhibits antitumor, diuretic and antihypertensive effects in vivo[1][2][3][4].

• Product Name Alternative:

  Diphyllin O-glucoside

• UNSPSC:

  12352005

• Target:

  SARS-CoV

• Type:

  Natural Products

• Related Pathways:

  Anti-infection

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Infection; Metabolic Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/cleistanthin-b.html

• Purity:

  98.19

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)=C2CO1

• Molecular Formula:

  C27H26O12

• Molecular Weight:

  542.49

• References & Citations:

  [1]Stefanik M, et, al. Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2. Microorganisms. 2021 Feb 25;9 (3) :471.|[2]Thummar VR, et, al. Evaluation of in vivo antitumor activity of cleistanthin B in Swiss albino mice. J Tradit Complement Med. 2015 Sep 3;6 (4) :383-388.|[3]Parasuraman S, et, al. Diuretic effects of cleistanthin a and cleistanthin B from the leaves of cleistanthus collinus in wistar rats. J Young Pharm. 2012 Apr;4 (2) :73-7.|[4]Priyadharsini RP, et, al. Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B. J Basic Clin Pharm. 2014 Sep;5 (4) :109-14.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [30021-77-3]