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MM41

CAT: 0804-HY-16967-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16967-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MM41 is a quadruplex-interacting compound. MM41 binds tightly to quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. MM41 reduces BCL-2 and k-RAS protein levels, increases caspase 3. MM41 has antitumor effects against pancreatic cancer[1].
CAS Number
1429028-96-5
UNSPSC
12352005
Target
Bcl-2 Family; Caspase; G-quadruplex; Ras
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mm41.html
Purity
98.89
Solubility
DMSO : 33.33 mg/mL (ultrasonic; adjust pH to 8 with HCl)
Smiles
O=C1C2=CC(NCCCN3CCN(CC3)C)=C4C(N(CCCN5CCOCC5)C(C6=CC(NCCCN7CCN(CC7)C)=C(C2=C64)C(N1CCCN8CCOCC8)=O)=O)=O
Molecular Formula
C44H66N10O6
Molecular Weight
831.06
References & Citations
[1]Ohnmacht SA, et al. A G-quadruplex-binding compound showing anti-tumour activity in an in vivo model for pancreatic cancer. Sci Rep. 2015 Jun 16;5:11385.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Caspase 3; K-Ras

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MBS5785994MM41

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