G-1

• Description :

  G-1 is a nonsteroidal, high-affinity and selective agonist of GPR30 with a Ki of 11 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H372, H400

• Target :

  Estrogen Receptor/ERR

• Type :

  Reference compound

• Related Pathways :

  Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/G-1.html

• Purity :

  99.76

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  BrC1=C([C@H]2[C@]3([H])[C@](C=CC3)([H])C4=CC(C(C)=O)=CC=C4N2)C=C5C(OCO5)=C1

• Molecular Formula :

  C21H18BrNO3

• Molecular Weight :

  412.28

• Precautions :

  H302, H372, H400

• References & Citations :

  [1]Cheng Q, et al. G-1 exerts neuroprotective effects through G protein-coupled estrogen receptor 1 following spinal cord injury in mice. Biosci Rep. 2016 Aug 31;36 (4) . pii: e00373.|[2]Kurt AH, et al. Oxidative/antioxidative enzyme-mediated antiproliferative and proapoptotic effects of the GPER1 agonist G-1 on lung cancer cells. Oncol Lett. 2015 Nov;10 (5) :3177-3182.|[3]Chimento A, et al. GPER agonist G-1 decreases adrenocortical carcinoma (ACC) cell growth in vitro and in vivo. Oncotarget. 2015 Aug 7;6 (22) :19190-203.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [881639-98-1]