Clofibrate-d4

CAT: 0804-HY-B0287S-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0287S-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Clofibrate-d4 is the deuterium labeled Clofibrate. Clofibrate is an agonist of PPAR, with EC50s of 50 μM, ∼500 μM for murine PPARα and PPARγ, and 55 μM, ∼500 μM for human PPARα and PPARγ, respectively.
CAS Number
[1189654-03-2]
UNSPSC
12352005
Target
Isotope-Labeled Compounds; PPAR
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Solubility
10 mM in DMSO
Smiles
CCOC(C(C)(C)OC1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)=O
Molecular Formula
C12H11D4ClO3
Molecular Weight
246.72
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Willson TM, et al. The PPARs: from orphan receptors to drug discovery. J Med Chem. 2000 Feb 24;43 (4) :527-50.|[3]Chen Y, et al. Clofibrate Attenuates ROS Production by Lipid Overload in Cultured Rat Hepatoma Cells. J Pharm Pharm Sci. 2017;20 (0) :239-251.|[4]Chen SH, et al. Prenatal PPARα activation by clofibrate increases subcutaneous fat browning in male C57BL/6J mice fed a high-fat diet during adulthood. PLoS One. 2017 Nov 2;12 (11) :e0187507.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B0287-01Clofibrate
HY-B1520Aluminium clofibrate
HY-B0287R-01Clofibrate (Standard)
HY-107348-01Etofylline clofibrate
HY-107348R-01Etofylline clofibrate (Standard)
HY-151912S-01Picolinafen-d4 (4-Fluorophenyl-d4)
HY-132468SKeto Pioglitazone-d4 (M-III-d4)
HY-W654154Dexmedetomidine-d4 L-tartrate (-d4-major)
HY-151892SGlimepiride-d4 (phenylethyl-α, α, β, β-d4) (cis/trans)
HY-151910S(±) -Fluoxetine-d4 Oxalate (trifluoromethylphen-d4-oxy)

Alternative Products

CatalogName
TRC-C586912-1MGClofibrate-d4
MBS6092206-01Clofibrate-d4 (Ethyl Clofibrate-d4, Ethyl 2-(4-chlorophenoxy-d4)-2-methylpropionate)
C5843-57Clofibrate-d4 (Ethyl Clofibrate-d4, Ethyl 2- (4-chlorophenoxy-d4) -2-methylpropionate)
MBS577402Clofibrate
MBS5772959Aluminimum clofibrate
70-1055Clofibrate antibody
A10229-1000Clofibrate 1g

Popular Products