Costunolide

• Description:

  Costunolide ((+) -Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].

• Product Name Alternative:

  (+) -Costunolide; Costus lactone

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H317, H319, H335

• Target:

  Apoptosis; Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Costunolide.html

• Purity:

  99.69

• Solubility:

  DMSO : 233.33 mg/mL (ultrasonic) |Ethanol : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(O[C@@]1([H])[C@@]2([H])CC/C(C)=C/CC/C(C)=C/1)C2=C

• Molecular Formula:

  C15H20O2

• Molecular Weight:

  232.32

• Precautions:

  H315, H317, H319, H335

• References & Citations:

  [1]Dae Yong Kim, et al. Costunolide-A Bioactive Sesquiterpene Lactone with Diverse Therapeutic Potential. Int J Mol Sci. 2019 Jun; 20 (12) : 2926.|[2]Minyan Wei, et al. Costunolide induces apoptosis and inhibits migration and invasion in H1299 lung cancer cells. Oncol Rep. 2020 Jun;43 (6) :1986-1994.|[3]Zhangxiao Peng, et al. Costunolide and dehydrocostuslactone combination treatment inhibit breast cancer by inducing cell cycle arrest and apoptosis through c-Myc/p53 and AKT/14-3-3 pathway.Sci Rep. 2017; 7: 41254.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [553-21-9]