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Azaribine

CAT: 0804-HY-B1537-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1537-01Size:5 mg
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Description
Azaribine (2',3',5'-Tri-O-acetyl-6-azauridine) is a potent orotidine monophosphate decarboxylase (OMPD) inhibitor. Azaribine is an antiviral inhibitor of several RNA viruses and inhibits viral genome replication and gene transcription. Azaribine shows broad-spectrum antiviral activity (EC50=3.80 nM-1.73 μM against influenza A and B viruses; EC50=1.62 μM against ZIKV Paraiba) . Azaribine, a triacetate salt of Azauridine, has the potential for psoriasis research[1][2].
CAS Number
2169-64-4
Product Name Alternative
2',3',5'-Tri-O-acetyl-6-azauridine
UNSPSC
12352005
Target
Influenza Virus; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/azaribine.html
Purity
99.0
Solubility
DMSO : 3.8 mg/mL (ultrasonic; warming)
Smiles
CC(OC[C@@H]1[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](N2N=CC(NC2=O)=O)O1)=O
Molecular Formula
C14H17N3O9
Molecular Weight
371.30
References & Citations
[1]Jun-Gyu Park, et al. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses. J Virol. 2020 Mar 17;94 (7) :e02149-19.|[2]Desarey Morales Vasquez, et al. Identification of Inhibitors of ZIKV Replication. Viruses. 2020 Sep 18;12 (9) :1041.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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