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Eliapixant

CAT: 0804-HY-109170-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109170-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Eliapixant (BAY 1817080) is a potent and selective antagonist of P2X3 receptor, with an IC50 of 8 nM. Eliapixant can be used for the research of refractory chronic cough[1][2].
CAS Number
1948229-21-7
Product Name Alternative
BAY 1817080
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/eliapixant.html
Purity
99.95
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@H](C1=CN=C(C(F)(F)F)N=C1)NC(C2=CC(O[C@@H]3CCOC3)=CC(C4=NC=C(S4)C)=C2)=O
Molecular Formula
C22H21F3N4O3S
Molecular Weight
478.49
References & Citations
[1]Morice A, et, al. Eliapixant (BAY 1817080), a P2X3 receptor antagonist, in refractory chronic cough: a randomised, placebo-controlled, crossover phase 2a study. Eur Respir J. 2021 May 13;2004240.|[2]Spinaci A, et, al. P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications. Front Pharmacol. 2021 Apr 13;12:653561.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P2X3 Receptor

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CatalogName
BA6856-50Eliapixant

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