AA9

• Description :

  AA9 is a potent Transglutaminase 2 (TG2) inhibitor. AA9 strongly impacts HIF-mediated hypoxia in MDA-MB-231 cells[1].

• UNSPSC :

  12352005

• Target :

  Glutaminase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/aa9.html

• Smiles :

  O=C(OCC1=CC=CC=C1)N[C@H](C(N2CCN(C(C3=C4C=CC=CC4=CC=C3)=O)CC2)=O)CCCCNC(C=C)=O

• Molecular Formula :

  C32H36N4O5

• Molecular Weight :

  556.65

• References & Citations :

  [1]Ancona P, et al. Transcriptomics Studies Reveal Functions of Transglutaminase 2 in Breast Cancer Cells Using Membrane Permeable and Impermeable Inhibitors. J Mol Biol. 2024 May 15;436 (10) :168569.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2134114-20-6]