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PDC31

CAT: 0804-HY-P4160-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P4160-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDC31 (THG113.31; ILGHXDYK) is an allosteric and non-competitive inhibitor of FP Prostaglandin Receptor. PDC31 is the D-amino acid-based oligopeptide, is used for smooth muscle contractile agent. PDC31 decreases the strength and duration of uterine contractions in vivo, which can be used for research of preterm labor and primary dysmenorrhea (PD) . PDC31 also enhances Ca2+-dependent large-conductance K+-channel in human myometrial cells[1][2].
CAS Number
634586-40-6
Product Name Alternative
THG113.31; ILGHXDYK
UNSPSC
12352209
Target
Prostaglandin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/pdc31.html
Purity
99.92
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
OC(C=C1)=CC=C1C[C@H](C(N[C@@H](C(O)=O)CCCCN)=O)NC([C@@H](CC(O)=O)NC([C@@H](CCCNC(N)=O)NC([C@H](NC(CNC([C@@H](CC(C)C)NC([C@H](N)[C@H](C)CC)=O)=O)=O)CC2=CN=CN2)=O)=O)=O
Molecular Formula
C45H71N13O13
Molecular Weight
1002.12
References & Citations
[1]Sharif NA, et al. Prostaglandin FP receptor antagonists: discovery, pharmacological characterization and therapeutic utility. Br J Pharmacol. 2019 Apr;176 (8) :1059-1078. |[2]Doheny HC, et al. THG113.31, a specific PGF2alpha receptor antagonist, induces human myometrial relaxation and BKCa channel activation. Reprod Biol Endocrinol. 2007 Mar 16;5:10. |[3]Friel AM, et al. Specific PGF (2alpha) receptor (FP) antagonism and human uterine contractility in vitro. BJOG. 2005 Aug;112 (8) :1034-42. |[4]Böttcher B, et al. A first-in-human study of PDC31 (prostaglandin F2α receptor inhibitor) in primary dysmenorrhea. Hum Reprod. 2014 Nov;29 (11) :2465-73.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Phase 1
Isoform
FP

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