Bumetanide-d5

• Description :

  Bumetanide-d5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with ?IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

• UNSPSC :

  12352005

• Target :

  NKCC

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Purity :

  99.82

• Solubility :

  10 mM in DMSO|DMF : ≥ 33mg/mL|DMSO : ≥ 25mg/mL|Ethanol : ≥ 14mg/mL

• Smiles :

  O=C(O)C1=CC(NCCCC)=C(OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(S(=O)(N)=O)=C1

• Molecular Formula :

  C17H15D5N2O5S

• Molecular Weight :

  369.45

• References & Citations :

  [1]Sandström PE1, et al. Evidence for diabetogenic action of bumetanide in mice.Eur J Pharmacol. 1988 May 20;150 (1-2) :35-41.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• CAS Number :

  [1216739-35-3]