Bumetanide-d5

• Description:

  Bumetanide-d5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with ?IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

• UNSPSC:

  12352005

• Target:

  NKCC

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Purity:

  99.82

• Solubility:

  10 mM in DMSO|DMF : ≥ 33mg/mL|DMSO : ≥ 25mg/mL|Ethanol : ≥ 14mg/mL

• Smiles:

  O=C (O) C1=CC (NCCCC) =C (OC2=C ([2H]) C ([2H]) =C ([2H]) C ([2H]) =C2[2H]) C (S (=O) (N) =O) =C1

• Molecular Formula:

  C17H15D5N2O5S

• Molecular Weight:

  369.45

• References & Citations:

  [1]Sandström PE1, et al. Evidence for diabetogenic action of bumetanide in mice.Eur J Pharmacol. 1988 May 20;150 (1-2) :35-41.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1216739-35-3