Bumetanide-d5

• UNSPSC Description:

  Bumetanide-d5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with  IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].

• Target Antigen:

  NKCC

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C1=CC(NCCCC)=C(OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(S(=O)(N)=O)=C1

• Molecular Weight:

  369.45

• References & Citations:

  [1]Sandström PE1, et al. Evidence for diabetogenic action of bumetanide in mice.Eur J Pharmacol. 1988 May 20;150(1-2):35-41.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  1216739-35-3