Bumetanide-d5

CAT: 0804-HY-17468S-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-17468S-01Size:500 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bumetanide-d5 is a deuterium labeled Bumetanide. Bumetanide is a selective Na+-K+-Cl- (NKCC1) inhibitor, weakly inhibits NKCC2, with ?IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively[1].
CAS Number
[1216739-35-3]
UNSPSC
12352005
Target
NKCC
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.82
Solubility
10 mM in DMSO|DMF : ≥ 33mg/mL|DMSO : ≥ 25mg/mL|Ethanol : ≥ 14mg/mL
Smiles
O=C(O)C1=CC(NCCCC)=C(OC2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C(S(=O)(N)=O)=C1
Molecular Formula
C17H15D5N2O5S
Molecular Weight
369.45
References & Citations
[1]Sandström PE1, et al. Evidence for diabetogenic action of bumetanide in mice.Eur J Pharmacol. 1988 May 20;150 (1-2) :35-41.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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