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Lorpucitinib

CAT: 0804-HY-109182-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-109182-01Size:1 mg
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Description
Lorpucitinib (JNJ-64251330) is an orally active pan-JAK inhibitor with good enteric selectivity and safety. Lorpucitinib can inhibit the JAK/STAT pathway and reduce the levels of inflammatory biomarkers in serum. Lorpucitinib can be used in the research of familial adenomatous polyposis and gastrointestinal inflammatory diseases[1][2].
CAS Number
2230282-02-5
Product Name Alternative
JNJ-64251330
UNSPSC
12352005
Target
JAK; STAT
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lorpucitinib.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCC(C)(O)C)CC1=NC2=CN=C(NC=C3)C3=C2N1[C@H]4CC[C@H](CC#N)CC4
Molecular Formula
C22H28N6O2
Molecular Weight
408.50
References & Citations
[1]Hüneburg R, et al. Lorpucitinib (JNJ-64251330) in patients with familial adenomatous polyposis (FAP) : Results from a phase 1b study. 2023.|[2]Ma X, et al. A Phase I, Randomized, Multi‐Dose Study to Evaluate the Enteric Selectivity and Safety of JAK Inhibitor, Lorpucitinib, in Healthy Participants. Clinical Pharmacology & Therapeutics, 2024, 115 (5) : 1075-1084.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Alternative Products

CatalogName
BA4920-1Lorpucitinib

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