Alternariol

• Description :

  Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II) . Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].

• CAS Number :

  [641-38-3]

• UNSPSC :

  12352005

• Hazard Statement :

  H300, H310, H330, H360

• Target :

  Androgen Receptor; Apoptosis; Estrogen Receptor/ERR; Topoisomerase

• Type :

  Natural Products

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/alternariol.html

• Purity :

  99.88

• Solubility :

  DMSO : 25 mg/mL (ultrasonic)

• Smiles :

  CC1=CC(O)=CC(O2)=C1C3=CC(O)=CC(O)=C3C2=O

• Molecular Formula :

  C14H10O5

• Molecular Weight :

  258.23

• Precautions :

  H300, H310, H330, H360

• References & Citations :

  Alternaria alternate

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported