Alternariol

• Description:

  Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II) . Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].

• UNSPSC:

  12352005

• Hazard Statement:

  H300, H310, H330, H360

• Target:

  Androgen Receptor; Apoptosis; Estrogen Receptor/ERR; Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/alternariol.html

• Purity:

  99.88

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  CC1=CC(O)=CC(O2)=C1C3=CC(O)=CC(O)=C3C2=O

• Molecular Formula:

  C14H10O5

• Molecular Weight:

  258.23

• Precautions:

  H300, H310, H330, H360

• References & Citations:

  Alternaria alternate

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  641-38-3