Alternariol

• UNSPSC Description:

  Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects[1][2][3][4][5].

• Target Antigen:

  Androgen Receptor; Apoptosis; Estrogen Receptor/ERR; Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/alternariol.html

• Purity:

  99.67

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC(O)=CC(O2)=C1C3=CC(O)=CC(O)=C3C2=O

• Molecular Weight:

  258.23

• References & Citations:

  [1]Fliszár-Nyúl E, et al. Interaction of Mycotoxin Alternariol with Serum Albumin. Int J Mol Sci. 2019 May 12;20(9). pii: E2352.|[2]Grover S, et al. The Alternaria alternate Mycotoxin Alternariol Suppresses Lipopolysaccharide-Induced Inflammation. Int J Mol Sci. 2017 Jul 20;18(7). pii: E1577.|[3]Eva-Maria Brugger, et al. Mutagenicity of the mycotoxin alternariol in cultured mammalian cells. Toxicol Lett. 2006 Jul 14;164(3):221-30. |[4]Chien-Hsun Huang, et al. Alternariol exerts embryotoxic and immunotoxic effects on mouse blastocysts through ROS-mediated apoptotic processes. Toxicol Res (Camb). 2021 Jun 16;10(4):719-732. |[5]Jian Xin, et al. Alternariol alleviates breast carcinoma by inhibiting cellular proliferation correlated with increased apoptotic events in rats. European Journal of Inflammation.Volume 20: 1–13

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  641-38-3