Ispinesib

• Description:

  Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.

• Product Name Alternative:

  SB-715992; CK-0238273

• UNSPSC:

  12352005

• Hazard Statement:

  H300+H330, H341

• Target:

  Apoptosis; Kinesin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Ispinesib.html

• Purity:

  99.74

• Solubility:

  DMSO : ≥ 125 mg/mL

• Smiles:

  O=C1N(CC2=CC=CC=C2)C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14

• Molecular Formula:

  C30H33ClN4O2

• Molecular Weight:

  517.06

• Precautions:

  H300+H330, H341

• References & Citations:

  [1]Lad L, et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47 (11) :3576-85.|[2]Purcell JW, et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res. 2010 Jan 15;16 (2) :566-76.|[3]Davis DA, et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer. 2006 Jan 24;6:22.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  Kinesin-5/Eg5/KSP

• CAS Number:

  [336113-53-2]