RegisterLogin

Ispinesib

CAT: 0804-HY-50759-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50759-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Ispinesib is a specific inhibitor of kinesin spindle protein (KSP), with a Ki app of 1.7 nM.
CAS Number
[336113-53-2]
Product Name Alternative
SB-715992; CK-0238273
UNSPSC
12352005
Hazard Statement
H300+H330, H341
Target
Apoptosis; Kinesin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Ispinesib.html
Purity
99.74
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C1N(CC2=CC=CC=C2)C([C@@H](C(C)C)N(CCCN)C(C3=CC=C(C)C=C3)=O)=NC4=CC(Cl)=CC=C14
Molecular Formula
C30H33ClN4O2
Molecular Weight
517.06
Precautions
H300+H330, H341
References & Citations
[1]Lad L, et al. Mechanism of inhibition of human KSP by ispinesib. Biochemistry. 2008 Mar 18;47 (11) :3576-85.|[2]Purcell JW, et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin Cancer Res. 2010 Jan 15;16 (2) :566-76.|[3]Davis DA, et al. Increased therapeutic potential of an experimental anti-mitotic inhibitor SB715992 by genistein in PC-3 human prostate cancer cell line. BMC Cancer. 2006 Jan 24;6:22.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Kinesin-5/Eg5/KSP

Related Products

CatalogName

Alternative Products

CatalogName
TRC-I918500-10MGIspinesib
A10486-50Ispinesib 50mg
A10486-100Ispinesib 100mg
MBS576097SB715992(Ispinesib)
A10486-5Ispinesib 5mg
A10486-10Ispinesib 10mg
SC0105-10mMIspinesib (SB-715992)

Popular Products