Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) (TFA)

Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) (TFA)

• UNSPSC Description: Interphotoreceptor Retinoid Binding Protein Fragment (IRBP) TFA, a 20-residue peptide and a major pathogenic epitope, is present in the first homologous repeat of the interphotoreceptor retinoid binding protein peptide (IRBP 161–180), which can induce posterior uveitis (EAU)[1].
• Target Antigen: Others
• Type: Peptides
• Related Pathways: Others
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/interphotoreceptor-retinoid-binding-protein-fragment-irbp-tfa.html
• Purity: 99.73
• Smiles: OC(C=C1)=CC=C1C[C@H](NC([C@H](CO)NC([C@H]([C@@H](C)CC)NC([C@H]([C@@H](C)CC)NC([C@H](CC2=CC=C(C=C2)O)NC([C@H]3N(CCC3)C([C@H]([C@@H](C)CC)NC(CNC([C@@H](N)CO)=O)=O)=O)=O)=O)=O)=O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC4=CN=CN4)C(N5[C@@H](CCC5)C(NCC(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@H](C(O)=O)CC(O)=O)=O)=O)CC6=CN=CN6)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
• Molecular Weight: 2323.52
• References & Citations: [3]Yang H, et al. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2795-804.|[1]Tang J, et al. Autoimmune uveitis elicited with antigen-pulsed dendritic cells has a distinct clinical signatureand is driven by unique effector mechanisms: initial encounter with autoantigen defines diseasephenotype. J Immunol. 2007 May 1;178(9):5578-87.|[2]Cortes LM, et al. Inhibitory peptide analogs derived from a major uveitogenic epitope protect from antiretinalautoimmunity by inducing type 2 and regulatory T cells. J Leukoc Biol. 2008 Aug;84(2):577-85.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
• Clinical Information: No Development Reported