Decanoic acid

CAT: 0804-HY-W015309-01Size: 500 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W015309-01Size:500 mg
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Description
Decanoic acid is a key component of the medium-chain triglyceride (MCT) found in coconut oil. Decanoic acid is a brain-penetrant and non-competitive inhibitor of AMPA receptor showing antiseizure activity in rats. Decanoic acid reduces tyrosinase activity and inhibits melanosome maturation. Decanoic acid suppresses the phosphorylation of c-Met and induced apoptosis in hepatocellular carcinoma (HCC) cells by inhibiting the expression of various oncogenic proteins, which is promising for research in the field of mTORC1 signaling, HCC and epilepsy[1][2][3].
CAS Number
[334-48-5]
UNSPSC
12352211
Hazard Statement
H315, H319, H412
Target
C-Met/HGFR; Endogenous Metabolite; Glutaminase; iGluR; Tyrosinase
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Decanoic_acid.html
Purity
99.92
Solubility
DMSO : ≥ 130 mg/mL
Smiles
CCCCCCCCCC(O)=O
Molecular Formula
C10H20O2
Molecular Weight
172.27
Precautions
H315, H319, H412
References & Citations
[1]Boison D, et, al. New insights into the mechanisms of the ketogenic diet. Curr Opin Neurol. 2017 Apr;30 (2) :187-192.|[2]Chang P, et al. Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain. 2016 Feb;139 (Pt 2) :431-43.|[3]Kim S, et, al. Selective production of decanoic acid from iterative reversal of β-oxidation pathway. Biotechnol Bioeng. 2018 May;115 (5) :1311-1320.|[4]Warren EC, et al. Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling[J]. Proc Natl Acad Sci U S A. 2020 Sep 22;117 (38) :23617-23625.|[5]Yang MH, et al. Decanoic Acid Exerts Its Anti-Tumor Effects via Targeting c-Met Signaling Cascades in Hepatocellular Carcinoma Model[J]. Cancers (Basel) . 2023 Sep 22;15 (19) :4681.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AMPA Receptor; Human Endogenous Metabolite

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