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PAPA NONOate

CAT: 0804-HY-134636-01Size: 5 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-134636-01Size:5 mg
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Description
PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C) . PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].
CAS Number
146672-58-4
UNSPSC
12352211
Hazard Statement
H302
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/papa-nonoate.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NCCCN(CCC)N(O)N=O
Molecular Formula
C6H16N4O2
Molecular Weight
176.22
Precautions
H302
References & Citations
[1]Rössig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274 (11) :6823-6.|[2]N Dashti, et al. Study of the effect of PAPA NONOate on the rate of diabetic wound healing. African Journal of Biotechnology. 2014.|[3]Keefer LK, et al. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods Enzymol. 1996;268:281-93.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C, sealed storage, away from moisture and light
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

PAPA NONOate

PAPA NONOate is an alkylamine.

CAS Number146672-58-4
PubChem CID135503978
IUPAC Name(Z)-[3-aminopropyl(propyl)amino]-hydroxyimino-oxidoazanium
Molecular FormulaC6H16N4O2
Molecular Weight176.22
XLogP0.8
Topological Polar Surface Area90.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count12
Formal Charge0
Complexity140
SMILES
CCCN(CCCN)/[N+](=N/O)/[O-]
InChI
InChI=1S/C6H16N4O2/c1-2-5-9(6-3-4-7)10(12)8-11/h11H,2-7H2,1H3/b10-8-
InChIKey
QODRTFHTYGHQMT-NTMALXAHSA-N
Chemical Structure
2D Structure
2D structure of PAPA NONOate
CAS: 146672-58-4
CID: 135503978
Formula: C6H16N4O2
MW: 176.22
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight176.22
XLogP30.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass176.12732577
Monoisotopic Mass176.12732577
Topological Polar Surface Area90.6 Ų
Heavy Atom Count12
Formal Charge0
Complexity140
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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