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HTS07545

CAT: 0804-HY-144439-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-144439-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HTS07545 is a potent sulfide:quinone oxidoreductase (SQOR) inhibitor with an IC50 of 30 nM. HTS07545 reduces the decomposition rate of hydrogen sulfide (H2S) . HTS07545 can be used in the research of heart failure and pancreatic ductal adenocarcinoma.
CAS Number
118666-03-8
UNSPSC
12352005
Target
Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hts07545.html
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=C(C2=CC=CC=C2)C=C(C3=CC=CC=C3)N=C1OCC(OCC)=O
Molecular Formula
C22H18N2O3
Molecular Weight
358.39
References & Citations
[1]Simon D P Baugh, et al. Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase. Bioorg Med Chem Lett. 2021 Dec 15;54:128443. |[2]Lin Q, et al. Comprehensive analysis of SQOR involvement in ferroptosis resistance of pancreatic ductal adenocarcinoma in hypoxic environments. Front Immunol. 2025 May 1;16:1513589.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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